KETONE SUPPLEMENT

What are ketones?

Ketones (CnH2nO) are molecules composed of a carbonyl group (C = O) and two alkyl radicals (R); ketones derive from the oxidation of secondary alcohols by redox and, in the human organism, represent the "waste" of energy production (although some tissues are able to reuse them); when the blood concentrations of ketones (or ketone groups) are excessive (due to a diet lacking or too low in carbohydrates) they perform a "toxic action at the cellular level (especially for the nervous and renal systems) since their disposal is not effective enough to compensate for the buildup.

Why do ketones, while toxic, are the basis of many "extreme" weight loss diets today?

The slimming diets that cause the increase of ketones are used in the slimming field since these catabolites inhibit the nervous stimulus of the appetite; on the other hand, a question arises: being potentially harmful substances, what consequences could occur in the association of a ketogenic diet with raspberry ketone supplementation? Honestly, I would not experience them on my skin ..

Theory: efficacy and mechanism of action of supplements with raspberry ketone

The integration of ketones with raspberry ketone is recommended (by the company that markets it) in the performance of slimming diets such as fat-burners and in the NON-pharmacological treatment of oily-inelastic skins and baldness.
According to the American doctor Dr. Mehmed Oz, raspberry ketone is able to reduce adipose tissue by virtue of the "overall metabolic increase" of the organism, which is the mechanism that lies at the base of all other thermogenic supplements.
Some studies have observed the metabolic effects of raspberry ketone both on the guinea pig and on humans; the researchers therefore highlighted a correlation between the intake of raspberry ketone and:

Increase of "adiponectin (Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes; Anti-obese action of raspberry ketone - PUBMED)

Increased noradrenaline (catecholamine - hormone that also promotes lipolysis)

Increase in skin elasticity (Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans - PUBMED).

Stimulation of hair growth in subjects affected by alopecia.

It was therefore hypothesized that, in addition to promoting weight loss, the hormonal impact of raspberry ketone could significantly benefit even those with reduced glucose tolerance (including type 2 diabetes) or metabolic alterations of various kinds.
Ultimately, it is possible that the raspberry ketone supplement, inserted in the context of a low-calorie diet, can facilitate the reduction of adipose tissue, therefore generalized weight loss.

Method of use and side effects

At the moment there is not enough information to be able to establish a maximum intake dose; it is true that it is a food supplement and not a drug, however, by acting in a stimulating way on catecholamines (in a similar way to capsicin, at the synephrine, at the caffeine etc.) it is possible that excessive doses of raspberry ketone induce nervousness, sleep disturbances and all the side effects related to the abuse of thermogenic supplements (which are significantly aggravated by the "questionable" low-carb low-calorie diets).
Dosages of around 200mg / day of raspberry ketone supplements (not pure ketones!), Split into two 100mg intakes could be effective and considered safe.

NB. The raspberry ketone supplement is NOT RECOMMENDED during pregnancy, breastfeeding and development due to lack of specific information.