triggered by the Coronavirus SARS-CoV-2. This strategy involves the use of plasma, ie the liquid part of the blood, of patients recovered from the infection, in order to provide the sick with antibodies useful to counteract its effects. In practice, neutralizing immunoglobulins (Ig), involved in the immune response against the virus, are exploited for therapeutic purposes.
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In May 2020, clinical trials began to evaluate the efficacy of hyperimmune plasma infusions in COVID-19 affected individuals with severe breathing difficulties. Once infused into symptomatic patients, specific antibodies against SARS-CoV-2 ( isolated and purified from the plasma of convalescent patients) determine a rapid therapeutic response, with a reduction in viral load and an improvement in symptoms.
Hyperimmune plasma appears to be one of the most valid treatment options for dealing with the disease, but unfortunately there are some limitations and contraindications.
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