Nizatidine: What it is and Side Effects

belonging to the class of histamine H2 receptor antagonists.

Editorial board Nizatidine - Chemical Structure

Taken orally, nizatidine is indicated in the treatment of all those ailments strictly connected to an "excessive acid secretion from the stomach.

Once marketed within numerous medicinal specialties, currently (February 2020), in the Italian pharmaceutical market there is only one drug based on nizatidine with the trade name Nizax®; in order to be dispensed it requires a repeatable medical prescription (RR) ; however, being classified as a group A drug - in the foreseen cases (pathology exemption) - its cost can be reimbursed by the National Health System (SSN).

);

Relapsing ulcers;

Gastroesophageal reflux esophagitis.

with nizatidine, stomach tumors should be excluded. In fact, the use of the active ingredient could hide the symptoms of an ulcer caused by the aforementioned neoplasm, thus leading to a delay in diagnosis.

Before starting nizatidine therapy it is also important to inform your doctor if you have liver and / or kidney problems, as the active ingredient is partially transformed by the liver and almost completely eliminated by the kidneys.

Finally, it is recalled that the use of nizatidine in children is not recommended, as safety of use and efficacy in this category of patients are not known.

(OTC), herbal and phytotherapeutic products, homeopathic products, etc.

However, no interactions were observed between nizatidine and liver metabolized drugs such as aminophylline, theophylline, chlordiazepoxide, diazepam, metoprolol, lorazepam, lidocaine and phenytoin.

However, significant increases in blood salicylate levels have been observed following daily intake of high doses of acetylsalicylic acid (aspirin) (approximately 4 g per day) in combination with therapeutic doses of nizatidine.

, manifesting undesirable effects different in type and intensity, or not manifesting them at all.

Here are some of the side effects that may occur during treatment with nizatidine:

• Urticaria;
• Sweating;
• Drowsiness;
• Liver disorders with altered enzyme tests;
• Cholestatic jaundice and hepatitis;
• Mental confusion;
• Gynecomastia;
• Anemia, thrombocytopenia and thrombocytopenic purpura;
• Allergic reactions in sensitive individuals manifested with sudden narrowing of the airways and consequent difficulty in breathing;
• Skin rashes and exfoliative dermatitis;
• Increased blood concentration of uric acids not associated with gout or kidney stones;
• Increased levels of eosinophils in the blood
• Fever;
• Nausea.