The adjective defedato is reserved for individuals in a serious state of organic decay, resulting from more or less serious illnesses, drug addiction and / or malnutrition / malabsorption. The worsening of this general debilitation leads to cachexia or cachectic state.
Defied subjects, and even more cachectic ones, appear thin (loss of muscle mass), pale and languid, and are predisposed to various opportunistic diseases, from which a healthy and healthy organism is perfectly able to defend itself.