Generality
Myo-inositol is the most biologically active form of inositol.
Taken through the diet, through the consumption of bran, whole grains, brewer's yeast, citrus fruits and some meats, myo-inositol can also be minimally synthesized by the human body, starting from glucose.
In the clinical setting, the integration with myo-inositol, in light of its biological role as second messenger, has proved effective above all in the neurological and psychiatric fields.
Indications
Why is my-inositol used? What is it for?
Classically, myo-inositol is used in the clinical and integrative field for its marked antidepressant and anxiolytic activities.
These activities would be attributable to the biological role of this molecule.
Assembled in the plasma membrane in the form of phosphatidylinositol, myo-inositol can, under specific circumstances, induce the expression of second messengers and thus regulate gene expression and cellular activity.
More precisely, myo-inositol - thanks also to its ability to easily cross the blood-brain barrier - would seem to intervene directly on the serotoninergic signal, thus modulating the activity of different cortical areas.
Benefits and Properties
What benefits has my-inositol shown during the studies?
Although the neuro-psychiatric field certainly remains the most characterized field of application for myo-inositol, it is now possible to identify also new interesting emerging properties.
Myo-inositol and neurological pathologies
From recent scientific evidence, some also of a clinical nature, myo-inositol would have proved useful in managing complex neurological diseases, such as Alzheimer's disease and autism.
In these works, precisely in light of the regulatory role of myo-inositol, the integration with this molecule would have proved effective in controlling the clinical evolution of the pathology.
Greater degree of attention, improvement of perceptive and mnemonic abilities would be the main higher functions nourished by myo-inositol.
Myo-inositol and psychiatric disorders
Well characterized, also through clinical trials, is the role of myo-inositol in the management of psychiatric disorders, such as depression and obsessive-compulsive disorder.
According to several authors, the correct integration with myo-inositol, would determine a clear improvement of the symptoms, with a reduction in both the entity and the frequency of depressive and manic episodes.
Myo-inositol and gynecological pathologies
In recent years, the use of myo-inositol has aroused great interest also in the gynecological field.
More precisely, several authors have shown how the use of myo-inositol, combined with antioxidants such as alpha-lipoic acid, would determine a marked improvement in metabolic parameters in the course of polycystic ovary syndrome.
The improvement of the glycemic and insulinemic profile, the improvement of the lipid profile, the better balance of sex hormones and the possible correction of hyperandrogenism would be some of the main benefits of myo-inositol described in the course of both experimental and clinical studies.
The identification of the molecular mechanisms of action would allow us to clarify in more detail all the potential of myo-inositol and its isomers - such as d-chiro-inositol - in this clinical setting.
Dosage and method of use
How to use my-inositol
Unfortunately, it is not currently possible to define a standard and reproducible myo-inositol dose.
In the various studies, depending on the purpose of the supplement, dosages ranging from 1 to 12 grams per day were used, all of which proved to be very well tolerated.
More precisely, for the management of depression and panic attacks, the most effective dose seems to be precisely that of 12 g per day, taken continuously for at least 1 month.
Side effects
The use of myo-inositol has generally been shown to be safe and well tolerated.
The incidence of gastrointestinal reactions such as nausea, diarrhea and cramping abdominal pain has only rarely been observed.
Contraindications
When should my-inositol not be used?
The use of myo-inositol is contraindicated in case of hypersensitivity to the active principle.
Pharmacological interactions
What drugs or foods can modify the effect of my-inositol?
The use of myo-inositol at high doses could increase the biological effects of serotonin re-uptake inhibitors, such as fluoxetine or paroxetine.
Synergistic action also documented for the agonists of the 5-hydroxytryptamine receptors and for the St. John's wort.
Precautions for use
What do you need to know before taking my-inositol?
Given the lack of studies on long-term efficacy and safety during pregnancy and breastfeeding, it would be preferable to avoid the use of myo-inositol supplements at these stages of life.
Given the ability of myo-inositol, according to some authors, to worsen the symptoms of psychiatric pathologies such as bipolar disorder, it would be preferable to avoid its use in these clinical contexts.
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