Mannite, better known as D-mannitol, is a sugar, a monosaccharide that has long been known for its laxative virtues. Belonging to the category of polyols, mannitol can be industrially synthesized starting from sucrose, while the natural source of mannite par excellence is represented by manna; this is a sugary secretion that flows naturally from the ash tree (Fraxinus ornus L.) following incisions made by man or the bites of some insects.
Mannite as a laxative: doses and methods of assumption
Being an unabsorbable sugar, mannite acts as a perfect osmotic laxative, drawing water into the intestinal lumen. Enteric fluid retention increases fecal volume, mechanically stimulating peristalsis.
Dissolved in hot water or milk, at dosages between 10 and 30 grams per day, mannite is recommended as a mild laxative for the elderly and infancy (naturally at lower dosages, in the order of 2/15 g per day in relation to age).
Odorless, mannite has a slightly sweet and pleasant taste, which makes it a valid sugar substitute for diabetics and the products intended for them.
Mannite: side effects and contraindications
Mannite is well tolerated and at the recommended doses it causes neither colic nor nausea; for a greater laxative effect it can be associated, with due caution, to other substances with a purgative action. Like all laxatives, mannite is contraindicated in the presence of intestinal obstructions, as well as, of course, in the case of ascertained hypersensitivity.
Considering the frequent use in old age, it is good to remember that mannite can reduce the absorption of drugs taken at the same time orally, which should therefore be taken after at least 2-3 hours.
In high doses, it can cause flatulence and abdominal discomfort.
Finally, it should be remembered that the laxative effect of mannite is not immediate, but takes from 8-10 hours up to a couple of days.
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