Carnitine Liquid - Ultimate nutrition

About Carnitine Liquid - Ultimate nutrition

Food supplement of L carnitine.

FORMAT
355 ml bottle (liquid format)

COMPOSITION

Waterfall
Emulsifier: Vegetable glycerin
L carnitine
Pantothenic acid (Vitamin B5)

Preservatives: methyl parahydroxy benzoate and propyl parahydroxy benzoate

One dose (3ml measuring cap) contains:

L-Carnitine 200 mg - trimethylated amino acid derivative, mainly synthesized in the liver and kidney from two essential amino acids, such as methionine and lysine. The biological role of carnitine is now well established: this molecule is able to bind long-chain fatty acids and convey them through a membrane transporter into the mitochondrial matrix, where they undergo the oxidative process (with energy production).

During physical exercise carried out at 50 - 60% of VO2 max, fatty acids represent the main energy substrate to support performance; however, the physiological reduction of non-esterified carnitine levels, which occurs during the exercise itself, affects significantly on the maintenance of the oxidative, and therefore aerobic, capacities of the muscle subjected to stress, favoring the increase in glucose metabolism, which in turn further inhibits lipid oxidation (reducing the activity of the transporter for acyl carnitine). A muscle well supplied with carnitine could therefore better support lipid oxidation, saving muscle glycogen as an energy source. Carnitine, moreover, during intense lipid oxidation can regulate the AcetylCoA / CoA ratio by binding acetyl groups, therefore on the one hand avoiding the accumulation of acetyl groups, potentially harmful to the cell, and on the other hand increasing the availability of CoA, which is important for keeping the flow rate of the citric acid cycle high and thus favoring the production of energy

Pantothenic acid (Vitamin B5) 2 mg - also known as calcium pantothenate, it is part of the synthesis of Coenzyme A (ATP + VitB5 + Cys), which plays a key role in all the reactions in which the transfer of an acyl group takes place (oxidative decarboxylation of pyruvate, α-ketoglutarate and oxidation of fatty acids). It therefore plays a central role in both glucose and lipid metabolism, ensuring the positive control of the stages limiting oxidative processes.
This vitamin is easily introduced through the diet, found mainly in whole grains and in products of animal origin; consequently, there are no shortages in the well-fed population. Its daily requirement is estimated at around 6 mg, but it can definitely increase in particular categories such as athletes.

Product features Carnitine Liquid - Ultimate nutrition

This supplement offers an alternative form to capsules, namely the liquid form, which could be advantageous for those with swallowing problems and for the fastest transit of the digestive tract. However, the bioavailability seems to be the same as the capsule form (14/18%), significantly reduced compared to the dietary one.
The association with vitamin B5, could increase the levels of CoA, and enhance the cellular oxidative capacities. For the record, a 1996 study, however not subsequently studied, shows how the association of B vitamins, and in particular of the Choline, may increase the renal reabsorption of carnitine, increasing its blood concentration.

How to use recommended by the company - Carnitine Liquid - Ultimate nutrition

Take one dose (measuring cap) of 3ml once a day

Directions for use in sports Carnitine Liquid - Ultimate nutrition

The liquid form lends itself well to modulating the dosage, considering that in sports this can go up to 2.5 grams of L carnitine per day, despite the ministerial guidelines recommend a dose not exceeding 200 mg / day. Very high doses are useless, given the increased degradation in the intestine and the reduced reabsorption in the kidney. In sports this supplement is generally used for:

1. Increase lipid metabolism and facilitate fat loss;
2. Improve lipid oxidative metabolism, saving muscle glycogen;
3. Reduce muscle lactic fermentation, therefore also the sensation of fatigue;
4. Facilitate recovery

Furthermore, in a 2006 article, it was noted that carnitine supplementation in men undergoing physical exercise increased the expression of testosterone receptors in the muscles.

Rationale for use - Carnitine Liquid - Ultimate nutrition

The literature shows very conflicting studies on the efficacy of carnitine. The benefits of supplementation for those suffering from known diseases characterized by a deficiency of this substance are certain and documented. On the other hand, we get lost in the critical reading of the various articles published on the role. of carnitine supplementation in healthy individuals. Many studies, in fact, do not report any advantage in terms of athletic performance, weight loss and decrease in oxidative markers, while other studies show an increase in aerobic potential with a reduction in oxidative stress. However, it should be noted that these latest studies associate carnitine with controlled diets and intense and planned physical exercise ... but what is the role of carnitine in these benefits? What is the role of physical exercise? Which is the diet? Certainly, in order to record a benefit in terms of aerobic capacity, an increase in lipid metabolism, and therefore loss of fat mass, it is as clear as it is obvious to have to inevitably associate carnitine supplementation with a targeted diet program and mainly aerobic exercise.

Carnitine Liquid side effects - Ultimate nutrition

At high doses, episodes of insomnia, nausea, abdominal cramps, migraines and gastrointestinal disorders, although rare, may occur.

Precautions for use Carnitine Liquid - Ultimate nutrition

Contraindicated in cases of renal, hepatic, diabetic, pregnancy, lactation, mood disorders.

This article, elaborated on the critical rereading of scientific articles, university texts and common practice, is for information purposes only and therefore has no medical prescription value. It is therefore always required to consult your doctor, nutritionist or pharmacist before undertaking the use of any supplement.. Learn more about the critical analysis of Carnitine Liquid - Ultimate nutrition.

BIBLIOGRAPHY

J Physiol. 2007 June 1; 581 (Pt 2): 431-44

New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscleFrancis B Stephens, Dumitru Constantin-Teodosiu, and Paul L Greenhaff

Ann N Y Acad Sci. 2004 Nov; 1033: 30-41.

Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism Rebouche CJ.

J Appl Physiol. 1988 Jun; 64: 2394-9.

Influence of carnitine supplementation on muscle substrate and carnitine metabolism during exercise. Soop M, Björkman O, Cederblad G, Hagenfeldt L, Wahren J.

Carnitine for fatigue in multiple sclerosis.

Tejani AM, Wasdell M, Spiwak R, Rowell G, Nathwani S. Cochrane Database Syst Rev. 2010 Feb 17; 2: CD007280.

[Clinical and biochemical studies in a case of acute encephalopathy associated with calcium hopanthenate administration]

Kajita M, Iwase K, Matsumoto M, Kuhara T, Sinka T, Matsumoto I. Department of Pediatrics, Kohseiren Kamo Hospital, Aichi.
Mol Genet Metab. 2001 Aug; 73: 287-97.

Carnitine transport by organic cation transporters and systemic carnitine deficiency.

Lahjouji K, Mitchell GA, Qureshi IA. Division of Medical Genetics, Hôpital Sainte-Justine, 3175 Cote Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada.

L-Carnitine in the treatment of fatigue in adult celiac disease patients: a pilot study.

Ciacci C, Peluso G, Iannoni E, Siniscalchi M, Iovino P, Rispo A, Tortora R, Bucci C, Zingone F, Margarucci S, Calvani M.

Oxidative stress in response to aerobic and anaerobic power testing: influence of exercise training and carnitine supplementation.

Bloomer RJ, Smith WA.
Res Sports Med. 2009 Jan-Mar; 17: 1-16.

and Sci Sports Exerc. 2006 Jul; 38: 1288-96.

Androgenic responses to resistance exercise: effects of feeding and L-carnitine.

Wraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM.

J Strength Cond Res. 2008 Jul; 22: 1130-5.

Effects of L-carnitine L-tartrate supplementation on muscle oxygenation responses to resistance exercise.

Spiering BA, Kraemer WJ, Hatfield DL, Vingren JL, Fragala MS, Ho JY, Thomas GA, Häkkinen K, Volek JS.