POLARAMIN ® is a drug based on Desclofeniramina maleate
THERAPEUTIC GROUP: Antipruritic, including antihistamines, anesthetics etc.
Indications POLARAMIN ® Desclofeniramina
POLARAMIN ® is indicated in the symptomatic treatment of pruritic dermatitis, sun and erythema and insect bites.
Mechanism of action POLARAMIN ® Desclofeniramina
Desclofeniramina, the active ingredient of POLARAMIN ®, is the dextrorotatory isomer of the more famous Chlorpheniramine, therefore endowed with effective biological anticholinergic, antihistamine and modestly sedative properties.
The aforementioned therapeutic properties are attributable to the ability of the active ingredient to compete with histamine for binding to H1 receptors, thus inhibiting the biological activity of histamine and controlling vasodilation, inflammation, pain and edema induced by this. mediator.
The topical use of POLARAMIN ® also limits the systemic absorption of the active principle, significantly reducing the potential side effects classically linked to the systemic use of antihistamines such as those affecting the central nervous system.
All this makes the administration of POLARAMIN ® effective and safe for the treatment of minor skin diseases such as itchy dermatitis, insect bites and sunburn, supported by biological mediators such as histamine.
Studies carried out and clinical efficacy
TREATMENT OF GYNECOLOGICAL ITCH
Ann Pharmacother. 1994 Jan; 28: 17-20.
Strategy of treatment of pruritus during pregnancy. The Drugs and Pregnancy Study Group.
Italian study that evaluates the efficacy of Desclorfeniramina in the treatment of gynecological pruritus, evaluating the efficacy and safety of this active principle compared to others commonly used. Unfortunately, the results obtained do not allow to define the safety profile of the drug for the health of the fetus.
DESCHLORPHENIRAMINE HEPATITIS
Gastroenterol Clin Biol. 1998 Oct; 22: 831-2.
[Dexchlorpheniramine-induced acute hepatitis: a case with positive rechallenge].
Remy AJ, Debette M, Diaz D, Voigt JJ, Blanc P, Larrey D.
Yet another case report that denounces the onset of acute hepatitis in a patient undergoing treatment with Desclorfeniramina, reiterating the importance of respecting the therapeutic indications and related contraindications
ANAPHYLAXIS FROM DESCHLORPHENIRAMINE
Eur J Dermatol. 2007 Mar-Apr; 17: 170-1. Epub 2007 Mar 2.
Anaphylactic reaction to ranitidine and dexchlorpheniramine.
Thurot-Guillou C, Bourrain JL, Jacquier JP, Beani JC.
Case report denouncing the onset of an anaphylactic reaction to dechlorpheniramine, so severe as to require hospitalization and immediate suspension of therapy.
Method of use and dosage
POLARAMIN ®
Dermatological cream with 1% of Desclorfeniramina maleate.
It is generally recommended to apply the appropriate amount of cream directly on the skin region characterized by the pathological process 2-3 times a day, taking care to gently massage the area in order to ensure its complete absorption.
POLARAMIN ® Desclofeniramina warnings
Although the use of POLARAMIN ® is generally well tolerated, it is advisable for the patient to comply with some sanitary rules useful to limit the onset of potential side effects and to optimize therapeutic efficacy.
Thoroughly cleanse your hands after applying the cream, avoid contact of the medicine with eyes and mucous membranes, avoid applying the cream to particularly extensive skin regions affected by exuding and secreting pathological processes, avoid direct exposure to solar radiation. only the main warnings for the use of POLARAMIN ®.
It is generally recommended to keep the drug out of the reach of children.
PREGNANCY AND BREASTFEEDING
The use of POLARAMIN ® during pregnancy and in the subsequent period of breastfeeding should take place under the strict supervision of your doctor and only in case of real need.
Interactions
No drug interactions worthy of clinical note are currently known.
Contraindications POLARAMIN ® Desclofeniramina
The use of POLARAMIN ® is contraindicated in patients hypersensitive to the active substance or to one of its excipients.
Undesirable Effects - Side Effects
The use of POLARAMIN ®, especially when prolonged for a long time, could cause the appearance of local and transient adverse reactions such as burning, skin rashes, dry skin and photosensitization.
Note
POLARAMIN ® is a drug not subject to mandatory medical prescription.
The information on POLARAMIN ® Desclofeniramina published on this page may be out of date or incomplete. For a correct use of this information, see the Disclaimer and useful information page.
