ISOTREXIN® is a drug based on Isotretinonin and Erythromycin
THERAPEUTIC GROUP: Anti-acne preparations for topical use
Indications ISOTREXIN ® Isotretinoin + Erythromycin
ISOTREXIN® is used in the treatment of mild and moderate acne.
Mechanism of action ISOTREXIN ® Isotretinoin + Erythromycin
ISOTREXIN® is a drug consisting of two different active ingredients with complementary therapeutic activities, capable of optimizing the clinical efficacy of the drug in the best possible way.
More precisely, Isotretinonin, an acid derivative of vitamin A, performs a keratolytic and proliferative action by exfoliating the most superficial keratinized layers and controlling the sebaceous secretion of the gland, subsequently allowing a re-epithelialization useful to uniform the superficial skin layer.
Erythromycin, on the other hand, a macrolide capable of inhibiting bacterial protein synthesis by structurally interfering with the 50S ribosomal subunit, is able to control the proliferation of Proprionibacterium acnes, a microorganism involved in the pathogenesis of acne and partly responsible for the inflammatory evolution of lesions comedonic skin.
The association of the two active principles therefore allows to optimize the therapeutic efficacy of the drug, while guaranteeing adequate control of the potential side effects classically linked to systemic therapy and instead minimized by topical use.
Studies carried out and clinical efficacy
ISOTRETINONIN AND ANTIBIOTIC: GREAT CLINICAL EFFECTIVENESS
Clin Drug Investig. 2011; 31: 599-604. doi: 10.2165 / 11539570-000000000-00000.
Combination of low-dose isotretinoin and pulsed oral azithromycin in the management of moderate to severe acne: a preliminary open-label, prospective, non-comparative, single-center study.
De D, Kanwar AJ.
This work demonstrates how the addition of an antibiotic to Isotretinonin can guarantee better clinical efficacy, significantly reducing the extent of inflammatory lesions and the severity of the disease itself.
ISOTRETINONIN AND RESISTANT MICROORGANISMS
Br J Dermatol. 2005 Dec; 153: 1126-36.
Efficacy of oral isotretinoin in the control of skin and nasal colonization by antibiotic-resistant propionibacteria in patients with acne.
Coates P, Vyakrnam S, Ravenscroft JC, Stables GI, Cunliffe WJ, Leyden JJ, Johnson J, Eady EA, Cove JH.
Interesting work that demonstrates how oral treatment with Isotretinonin can also be so effective as to control the proliferation of antibiotic resistant bacteria, significantly improving the quality of life of the patient suffering from acne.
Erythromycin and pulsed light in the treatment of acne
Adv Biomed Res. 2012; 1: 70. doi: 10.4103 / 2277-9175.102974. Epub 2012 Oct 31.
Efficacy of intense pulsed light combined with topical erythromycin solution 2% versus topical erythromycinsolution 2% alone in the treatment of persistent facial erythematous acne macules.
Faghihi G, Isfahani AK, Hosseini SM, Radan MR.
Study that demonstrates how the association of pulsed light with topical antibiotic treatment with Erythromycin can significantly improve the extent of inflammatory lesions present in patients with moderate or severe acne
Method of use and dosage
ISOTREXIN®
Topical gel with 0.05% Isotretinonin and 2% Erythromycin.
The correct use of the drug, which should always be carried out under strict medical supervision, generally involves the application of the appropriate quantity of gel directly on the skin region affected by the pathological event once or twice a day, for several weeks.
Warnings ISOTREXIN ® Isotretinoin + Erythromycin
The use of ISOTREXIN® must necessarily be preceded by a careful medical examination useful to clarify the pathological event in progress and any prescriptive appropriateness.
In order to avoid the possible occurrence of adverse reactions, the patient receiving ISOTREXIN® should:
- avoid ingestion and contact of the gel with eyes and mucous membranes;
- clean your hands thoroughly after using the medicine;
- avoid exposure of the treated region to ultraviolet rays;
- avoid the use of the drug in case of burns or other dermatological pathologies.
It is also recommended to store the drug out of the reach of children.
PREGNANCY AND BREASTFEEDING
Given the absence of clinical trials able to fully clarify the potential teratogenic or toxic effects of the active ingredients contained in ISOTREXIN® for the fetus and the particularly worrying results of some experimental studies are known, it would be appropriate to extend the aforementioned contraindications to the use of drug also during pregnancy and the subsequent period of breastfeeding.
Interactions
The patient receiving ISOTREXIN® should avoid the concomitant intake of cortisone drugs and the application of other topical products, especially those with keratolytic activity.
Contraindications ISOTREXIN ® Isotretinoin + Erythromycin
The use of ISOTREXIN® is contraindicated in patients hypersensitive to the active ingredient or to one of its excipients and in patients with dermatological diseases.
Undesirable Effects - Side Effects
Numerous clinical trials and extensive post-marketing experience have shown how the use of Isotretinonin, especially in predisposed subjects or when prolonged for particularly long periods, can determine the onset of local adverse reactions such as burning, irritation, erythema, pain and itching. .
Fortunately, the most clinically relevant events and generally associated with drug hypersensitivity reactions are rarer.
Note
ISOTREXIN® is a drug subject to mandatory medical prescription.
The information on ISOTREXIN ® Isotretinoin + Erythromycin published on this page may be out of date or incomplete. For a correct use of this information, see the Disclaimer and useful information page.
