EXOCIN © is a drug based on Ofloxacin
THERAPEUTIC GROUP: Ophthalmological - antimicrobial
Indications EXOCIN ® Ofloxacin
EXOCIN ® is indicated in ophthalmology clinics for the treatment of blepharitis, conjunctivitis, blepharoconjunctivitis, keratitis and other external eye infections sustained by pathogenic microorganisms sensitive to Fluoroquinolones.
This antimicrobial has also proved effective in post-operative prophylaxis, avoiding the overlap of infections.
Mechanism of action EXOCIN ® Ofloxacin
Ofloxacin, the active ingredient of EXOCIN ®, is a synthetic fluroquinolone usually used to deal with external ocular infections, thanks to its ability to reach therapeutically effective concentrations following topical-ocular administration.
Its therapeutic activity, like that of the other second generation fluoroquinolones, is determined by the ability to inhibit the bacterial DNA-gyrase enzyme, important in assisting together with the various topoisomerases the duplication of DNA, necessary for bacterial replication.
This inhibition therefore materializes in the important bacteriostatic activity that controls the proliferation and microbial diffusion as well as the related symptoms.
The different studies have demonstrated the antimicrobial efficacy of Ofloxacin also against different microbial species normally resistant to common antibiotic therapy, and therefore responsible for recurrent infections with difficult therapeutic resolution.
Studies carried out and clinical efficacy
1. SAFETY OF OFLOXACIN THERAPY
Eur J Ophthalmol. 2006 May-Jun; 16: 359-64.
Prospective randomized study determining whether a 3-day application of ofloxacinresults in the selection of fluoroquinolone-resistant coagulase-negative Staphylococcus.
Ta CN, He L, Nguyen E, De Kaspar HM.
This work demonstrates how the administration of Ofloxacin according to defined therapeutic regimens does not in any way favor the onset of microbial strains resistant to fluoroquinolone therapy.
2. OFLOXACIN RETINOPATHY
Hum Exp Toxicol. 2008 May; 27: 409-15.
Ofloxacin-associated retinopathy in rabbits: role of oxidative stress.
Rampal S, Kaur R, Sethi R, Singh O, Sood N.
Experimental study conducted on laboratory animals which demonstrates how the prolonged use of Ofloxacin, inducing photosensitivity, can determine the onset of retinopathy, probably associated with an oxidative genesis.
3.NEW RELEASE SYSTEMS FOR OFLOXACIN
Pak J Pharm Sci. 2009 Apr; 22: 175-9.
Sustained ophthalmic delivery of ofloxacin from an ion-activated in situ gelling system.
Abraham S, Furtado S, Bharath S, Basavaraj BV, Deveswaran R, Madhavan V.
Work that demonstrates how the various efforts of the various research groups in identifying a delivery system that reduces the number of ophthalmic administrations to a minimum, can improve compliance and therapeutic efficacy
Method of use and dosage
EXOCIN ®
0.3% Ofloxacin eye drops.
Ofloxacin 0.3% ophthalmic ointment.
The therapeutic scheme should be defined by your doctor or ophthalmologist based on the severity of the clinical picture and the therapeutic objectives to be achieved.
Generally the administration of 1-2 drops 4-6 times a day should be effective for dealing with external eye infections.
EXOCIN ® Ofloxacin warnings
Although EXOCIN ® has high safety and few side effects, it would be necessary to consult your doctor or ophthalmologist before taking this drug.
Different studies have shown how patients treated with other systemic antibiotics can develop allergic side effects following the simultaneous administration of Ofloxacin, thus suggesting avoiding the contextual systemic and ophthalmic therapy.
EXOCIN ® eye drops contain benzalkonium chloride, a preservative with an irritating power, while the ophthalmic ointment lanolin, responsible for local reactions such as contact dermatitis.
The use of contact lenses at the same time as therapy with EXOCIN ® would therefore be avoided.
PREGNANCY AND BREASTFEEDING
The absence of clinical trials able to fully characterize the safety profile of Ofloxacin does not allow the free use of EXOCIN ® in pregnancy, and is therefore generally contraindicated.
Interactions
The topical ophthalmic use of Oflaxacin reduces to a minimum all the possible drug interactions described for the systemic use of the product.
However, it would be useful to avoid the simultaneous intake of non-steroidal anti-inflammatory drugs and possibly other ophthalmological preparations.
Contraindications EXOCIN ® Ofloxacin
The use of EXOCIN ® is contraindicated in patients hypersensitive to the drug or to one of its excipients, during the use of contact lenses and during pregnancy.
Undesirable Effects - Side Effects
The use of EXOCIN ® is generally well tolerated and devoid of clinically significant side effects, although the onset of eye irritation and discomfort has rarely been observed.
Note
EXOCIN ® is a drug subject to mandatory medical prescription.
The information on EXOCIN ® Ofloxacin published on this page may be out of date or incomplete. For a correct use of this information, see the Disclaimer and useful information page.
