DUAC® is a drug based on Benzoyl Peroxide + Clindamycin phosphate
THERAPEUTIC GROUP: Anti-acne preparations for topical use
Indications DUAC ® Benzoyl Peroxide + Clindamycin
DUAC® is used in the treatment of moderate and severe acne vulgaris, especially in the presence of inflammatory lesions.
Mechanism of action DUAC ® Benzoyl Peroxide + Clindamycin
DUAC® is a medicinal specialty that combines the therapeutic activity of two different active ingredients such as Benzoyl Peroxide and Clindamycin, thus enhancing the therapeutic and anti-acne potential.
More precisely, Benzoyl peroxide performs both a direct antiseptic action against Propionibacterium acnes and a modest exfoliating and keratolytic action, while Clindamycin, by inhibiting the 23 S ribosomal subunit, blocks protein synthesis and therefore the proliferation of Gram positive bacteria among the such as precisely P. acnes, carrying out at the same time a sensitive sebostatic action, important in reducing the sebaceous hypersecretion typical of acne pathology.
The combination of these two different active ingredients proved to be decidedly more effective than monotherapies, in regulating sebum secretion and inhibiting bacterial proliferation while also controlling the extent of inflammatory lesions.
Studies carried out and clinical efficacy
CLINICAL EFFECTIVENESS OF CLINDAMYCINE-BASED GELS
Int J Dermatol. 2013 Jun 20. doi: 10.1111 / ijd.12002. [Epub ahead of print]
Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris.
Khodaeiani E, Fouladi RF, Amirnia M, Saeidi M, Karimi ER.
Clinical trial that demonstrates how Clindamycin-based gels can be very effective in the treatment of acne vulgaris, guaranteeing a prompt remission of acne lesions, even inflamed ones.
CLINDAMYCIN / BENZOIC ACIC AND INNOVATIVE THERAPIES IN COMPARISON
J Drugs Dermatol. 2013 Mar; 12: 266-9.
Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris.
Baumann LS, Oresajo C, Yatskayer M, Dahl A, Figueras K.
Work that reaffirms the efficacy and clinical safety of the associated therapy between Benzoic acid and Clindamycin in the treatment of acne vulgaris, resulting as effective as innovative therapies.
CLINDAMYCIN AND BENZOYL PEROXIDE IN ACNE VOLGARE
Cutis. 2013 Feb; 91: 99-104.
Clindamycin phosphate 1.2% -benzoyl peroxide (5% or 2.5%) plus tazarotene cream 0.1% for the treatment ofacne.
Dhawan SS, Gwazdauskas J.
Clinical trial demonstrating how the treatment of moderate and severe acne vulgaris with Clindamycin plus Benzoyl Peroxide is effective and safe when applied for at least 12 weeks.
Method of use and dosage
DUAC®
Gel for topical use with 1 Clindamycin and 5% Benzoyl Peroxide.
It is generally recommended to apply the correct amount of gel on the skin region affected by the inflammatory event once a day, preferably in the evening, gently massaging the area in order to optimize the absorption of the medicine.
The duration or any corrections of standard therapy should be defined by the competent physician.
Warnings DUAC ® Benzoyl Peroxide + Clindamycin
The patient treated with DUAC® should respect some important rules in order to keep the therapeutic efficacy of the drug high, avoiding the onset of unpleasant side effects.
More precisely it should:
- thoroughly cleanse the area to be treated before applying DUAC®;
- wash your hands after using the medicine;
- avoid ingestion and contact of the drug with eyes and mucous membranes;
- avoid the use of the medicine in case of contextual dermatological pathologies;
- avoid exposure of the treated region to sunlight.
It is also recommended to store the drug in a cool, dry place out of the reach of children.
PREGNANCY AND BREASTFEEDING
Given the absence of studies capable of fully characterizing the absorption and safety profile of the active ingredients contained in DUAC® for the health of the fetus and infant, it is preferable to avoid the use of the drug during pregnancy and in the subsequent period. breastfeeding.
Interactions
In order to preserve the safety of treatment with DUAC®, it would be preferable to avoid the simultaneous intake of cortisone and topical drugs, especially exfoliants or antiacneics.
Contraindications DUAC ® Benzoyl Peroxide + Clindamycin
The use of DUAC® is contraindicated in patients hypersensitive to the active ingredient or to one of its excipients and in patients suffering from dermatological diseases.
Undesirable Effects - Side Effects
The use of DUAC®, especially if prolonged for a long time or carried out on particularly sensitive patients, could determine the appearance of local adverse reactions such as irritation, desquamation, depigmentation, redness and burning.
Adverse reactions worthy of clinical note and such as to require discontinuation of treatment have only rarely been observed.
Note
DUAC® is a drug subject to mandatory medical prescription.
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