CISTIDIL ® L-cystine

CISTIDIL ® is an L-Cystine based drug

THERAPEUTIC GROUP: Other dermatological preparations

Indications CISTIDIL ® L-cystine

CISTIDIL® is used as an adjuvant in the treatment of acne, atrophic dermatitis and psoriasis.

Mechanism of action CISTIDIL ® L-cystine

CISTIDIL ® is a drug based on L-Cystine, an extremely important amino acid from a biological point of view given the numerous patterns in which it falls.
The appropriate intake of this amino acid, especially in clinical conditions characterized by a significant increase in its requirement, would ensure:

• the correct synthesis of taurine and therefore of bile salts, fundamental in the hepatic detoxification processes;
• the appropriate synthesis of glutathione, one of the main cellular endogenous antioxidants;
• the correct synthesis of keratin, an important protein for the correct structuring of skin appendages such as nails, hair and hair;
• the correct synthesis of molecular mediators such as immunoglobulins and hormones fundamental in preserving the functioning of the organism.

All the aforementioned biological actions are adjuvant by excellent pharmacokinetic properties that allow the amino acid taken per os to be rapidly absorbed in the intestine by active transport and subsequently poured into the portal blood and made available for the various biological functions.

Studies carried out and clinical efficacy

CYSTINE IN THE PREVENTION OF DOXORUBICIN ALOPECIA
Arch Dermatol Res. 2013 Jan; 305: 25-34. doi: 10.1007 / s00403-012-1253-1. Epub 2012 Jun 15.

Chemoprevention of doxorubicin-induced alopecia in mice by dietary administration of L-cystine and vitamin B6.

D "Agostini F, Fiallo P, Ghio M, De Flora S.

Very interesting experimental study that demonstrates the efficacy of the combination of L-Cystine and vitamin B6 in counteracting alopecia induced by drugs such as doxorubicin, particularly aggressive chemotherapy drugs.

CYSTINE PROTECTIVE EFFECTS
Acta Otolaryngol. 1999; 119: 671-3.

Cystine protects cochlear outer hair cells against glutamate toxicity.

Sunami K, Yamane H, Takayama M, Nakagawa T, Konishi K, Iguchi H.

Yet another study that demonstrates the protective potential of cysteine ​​against cytotoxicity induced by agents such as glutamate, and often responsible for the loss of biological functionality.

CYSTINE AND KERTINOCYTES
Cutan Ocul Toxicol. 2006; 25: 13-22.

Xenobiotics in vitro: the influence of L-cystine, pantothenat, and miliacin on metabolic and proliferative capacity of keratinocytes.

Obrigkeit DH, Oepen T, Jugert FK, Merk HF, Kubicki J.

Experimental study conducted on keratinocyte cultures that demonstrates how Cystine can play an important role in stimulating the growth of these cells in monolayer, thus highlighting a possible connection with its biological effects

Method of use and dosage

CISTIDIL ®
500 mg tablets of L-Cystine
The appropriate therapeutic regimen should be defined by the physician based on the specific needs of the patient.
Generally it is recommended to take 2 to 4 tablets orally to be taken during meals.

CISTIDIL ® L-cystine warnings

CISTIDIL ® contains lactose among its excipients, therefore its intake is contraindicated in patients with lactase enzyme deficiency, glucose-galactose malabsorption syndrome and impaired lactose tolerance.
It is recommended to store the drug out of the reach of children.

PREGNANCY AND BREASTFEEDING

The use of CISTIDIL ® during pregnancy should only be carried out in cases of real need and always under the careful supervision of your gynecologist.

Interactions

No drug interactions worthy of clinical note are currently known.

Contraindications CISTIDIL ® L-cystine

The use of CISTIDIL ® is contraindicated in patients hypersensitive to the active substance or to one of its excipients, and in patients with cystinuria and kidney stones.

Undesirable Effects - Side Effects

No clinically relevant side effects are currently known.

Note

CISTIDIL ® is a drug subject to mandatory medical prescription.

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