BUSCOPAN ® is a drug based on hyoscine N-butylbromide.
The active ingredient is of vegetable origin, extracted from the Duboisia plant.
THERAPEUTIC GROUP: Spasmolytics
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Indications BUSCOPAN ® Butylscopolamine
BUSCOPAN ® is indicated in the treatment of painful manifestations due to spasms and cramps of the gastrointestinal and genitourinary tract.
Mechanism of action BUSCOPAN ® Butylscopolamine
BUSCOPAN ® administered orally or rectally is minimally absorbed, so much so that its systemic bioavailability is around 1%. However, this drug tends to concentrate mainly in the anatomical areas in which it exerts its therapeutic action. (gastrointestinal tract, gallbladder, hepatobiliary duct, liver and kidney).
BUSCOPAN ® administered at the prescribed doses does not cross the blood brain barrier, limiting the side effects associated with anticholinergics, and is mostly excreted by the kidney.
The symptomatic action of BUSCOPAN ® is expressed through the competitive action against acetylcholine on the muscarinic receptors of the smooth muscle of the gastrointestinal tract, responsible for muscle excitation and contraction.
Studies carried out and clinical efficacy
Thomas Weiser, Stefan Just Hyoscine butylbromide potently blocks human nicotinic acetylcholine receptors in SH-SY5Y cells Neuroscience Letters P09-01138, 2009,450: 3 258-261
This study showed how the active ingredient of BUSCOPAN ® can have an antispasmodic efficacy in the intestine about 7 times higher than other spasmolytics. Probably this effect could be associated, as the study conducted on human nerve cells shows, with the inhibitory effect. also exerted on the neuronal nicotinic receptors of the ganglia of the enteric autonomic nervous system, assisting the inhibitory effect exerted on the muscarinic receptors of the visceral musculature.
J Gastrointestin Liver Dis. 2009 Mar; 18: 17-22.
Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics).
Khalif IL, Quigley EM, Makarchuk PA, Golovenko OV, Podmarenkova LF, Dzhanayev YA.
This study, conducted on 118 patients with irritable bowel syndrome, has shown that BUSCOPAN ® administered both in the form of coated tablets and suppositories - determines a significant improvement in intestinal pain and in the threshold of rectal discomfort, especially in patients characterized by predominant diarrhea.
Eur J Gastroenterol Hepatol. 2006 Jan; 18: 63-8.
Tolerance to gastric distension in patients with functional dyspepsia: modulation by a cholinergic and nitrergic method.
Bouin M, Lupien F, Riberdy-Poitras M, Poitras P.
The study shows how BUSCOPAN ® used on patients suffering from dyspepsia (recurrent pain and discomfort in the stomach), guaranteed an improvement in symptoms in 77% of cases, thanks to the improved gastric distension induced by the drug.
Method of use and dosage
BUSCOPAN ® 10 mg coated tablets: for adults and children over 14 years of age, 1 - 2 tablets 3 times a day.
BUSCOPAN ® 10 mg suppositories: 1 suppository 3 times a day.
For children under the age of 14, the doctor's instructions must be strictly followed.
BUSCOPAN ® Butylscopolamine warnings
The use of anticholinergics, therefore of BUSCOPAN ® must be carried out with caution in the elderly, in patients with disorders of the autonomic nervous system, in cardiac tachyarrhythmias, in arterial hypertension, in congestive heart failure, in hyperthyroidism and in patients with liver and kidney diseases.
In general, anticholinergics can interfere with normal driving and concentration skills.
Avoid chewing BUSCOPAN ®
PREGNANCY AND BREASTFEEDING
Although no toxic effects occurred during pregnancy and lactation, nor teratogenic or embryotoxic effects on animal guinea pigs, it would be advisable to consult your doctor before taking BUSCOPAN ® during pregnancy, especially in the first trimester.
Interactions
BUSCOPAN ® can interfere with:
Tricyclic antidepressants, accentuating their effect.
Dopamine antagonists, reducing the effects of both drugs.
Beta-adrenergics, enhancing the tachycardic effect.
It is advisable not to take antacids and alcohol during the treatment, in order to avoid alterations in the metabolism of BUSCOPAN ®
Contraindications BUSCOPAN ® Butylscopolamine
BUSCOPAN ® is contraindicated in case of hypersensitivity to one of its components or metabolites, acute angle glaucoma, prostatic hypertrophy or other causes of urinary retention, pyloric stenosis and other conditions stenosing the gastrointestinal tract, paralytic ileus, ulcerative colitis, megacolon, esophagitis from reflux, intestinal atony of the elderly and debilitated subjects, and myasthenia gravis and in children under the age of 6 years.
Undesirable Effects - Side Effects
Therapeutic doses of BUSCOPAN ® can cause dry mouth, altered sweating, altered ocular tone, difficulty in urination and drowsiness.
High doses of BUSCOPAN ® can also be associated with the onset of tachycardia and alterations in cardiorespiratory function and cognitive abilities.
Skin rashes of various kinds can be associated with hypersensitivity to one of its components.
Note
BUSCOPAN ® is gluten and lactose free.
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