AMOX ® Amoxicillin

AMOX ® is a drug based on Amoxicillin

THERAPEUTIC GROUP: General antimicrobials for systemic use - broad spectrum penicillins

AMOX ® indications Amoxicillin

AMOX ® is a broad spectrum antibiotic used in the clinic in the antibiotic therapy of organ and system infections sustained by Gram positive and negative non-penicillinase producing bacteria.
In combination with pantoprazole and clarithromycin amoxicillin can also be used in the therapy for the eradication of Helicobacter Pylori.

Mechanism of action AMOX ® Amoxicillin

AMOX ®, an amoxicillin-based drug, is an antibiotic particularly used in the clinical setting due to its great versatility of action which makes it effective against infections sustained by both positive and negative Gram bacteria.
The particular chemical structure, characterized by the addition of a hydroxyl group with respect to ampicillin, significantly influences its pharmacokinetic properties, giving the active ingredient a natural resistance to acidic environments which guarantees effective and rapid absorption via the intestine even when taken for os.
However, the mechanism of microbicidal action remains the same as that commonly described for penicillins, carried out by the inhibition of the transpeptidation reaction which prevents the formation of cross-links at the peptidoglycan level, thus reducing the stability of the bacterial wall and thus facilitating its lysis. for osmotic shock.
After exerting its bactericidal action at the level of biological fluids and body tissues, amoxicillin is eliminated as it is by the kidney.

Studies carried out and clinical efficacy

1. THE COMPLIANCE THERAPEUTIC ALL "AMOXICILLIN
Respirology. 2012 May; 17: 687-92.

Comparison of adherence between twice- and thrice-daily regimens of oral amoxicillin / clavulanic acid.

Llor C, Bayona C, Hernández S, Moragas A, Miravitlles M.

Interesting study that demonstrates how the possibility of placing on the market more stable solutions based on amoxicillin, capable of reducing the daily frequency of intake, can lead to a significant improvement in the compliance of the therapy, increasing its effectiveness.

2 . HIGH DOSES OF AMOXICILLIN IN TRIPLE THERAPY IMPROVE THE ERADICATION RATE
Aliment Pharmacol Ther. 2012 May 17.

High-dose, ten-day esomeprazole, amoxicillin and metronidazole triple therapy achieves high Helicobacter pylori eradication rates.

Sánchez-Delgado J, GarcÃa-Iglesias P, Castro-Fernández M, Bory F, Barenys M, Bujanda L, Lisozain J, Calvo MM, Torra S, Gisbert JP, Calvet X.

Work conducted on over 100 patients suffering from gastro-enteric disorders associated with Helicobacter Pylori, which demonstrated how increasing conventional doses of amoxicillin can increase the efficacy of triple therapy, ensuring a greater degree of eradication of the microorganism.

3. LIVER DAMAGE FROM AMOXICILLIN
Korean J Hepatol. 2011 Sep; 17: 229-32.

A case of amoxicillin-induced hepatocellular liver injury with bile-duct damage.

Kim JS, Jang YR, Lee JW, Kim JY, Jung YK, Chung DH, Kwon OS, Kim YS, Choi DJ, Kim JH.

Case report demonstrating the onset of hepatocellular damage and hepatic cholestasis following amoxicillin intake. These cases underline the importance of medical supervision throughout antibiotic treatment.

Method of use and dosage

AMOX ®
1 g amoxicillin tablets;
The dosage schedule for AMOX ® -based antibiotic treatment should be defined by your doctor based on the physio-pathological characteristics of the patient and his clinical picture.
The therapeutic range, generally comprised in adults between 1 and 3 grams of amoxicillin daily, could be revised in patients with liver and kidney diseases or the elderly.
The use of AMOX ® must necessarily be supervised by your doctor.

AMOX ® Amoxicillin Warnings

Before taking AMOX ® it is necessary to consult your doctor and evaluate the possible presence of allergies to penicillins and cephalosporins, the presence of which would seriously compromise the patient's health following the intake of amoxicillin.
The doctor should also evaluate the sensitivity of the pathogen to amipicillin by means of an antibiogram, administering the drug only in positive cases.
In fact, it is useful to reiterate how the inadequate use of the drug could contribute to the establishment of drug resistant microbial strains, therefore insensitive to amoxicillin therapy.
The doctor should periodically check the state of liver and kidney function of the patient undergoing therapy, stopping the treatment following the appearance of unwanted side effects.

PREGNANCY AND BREASTFEEDING

The use of AMOX ® during pregnancy should only be carried out in cases of real necessity and always under strict medical supervision.
Given the ability of amoxicillin to concentrate in breast milk, it would be advisable to avoid taking AMOX ® during breastfeeding.

Interactions

In order to reduce as much as possible the side effects of antibiotic therapy with AMOX ®, while safeguarding its therapeutic efficacy, it would be advisable to pay particular attention to the contextual intake of:

• Allopurinol, given the increased risk of developing allergic reactions;
• Probenecid, responsible for the increase in blood concentrations and the hepatic and renal side effects of amoxicillin;
• Warfarin, due to the increased risk of bleeding;
• Methotrexate, given the increase in blood concentrations of this active principle induced by amoxicillin, responsible for an increase in the toxicity of the drug;
• Ethanol and amiloride able to alter the intestinal absorption profile.

Contraindications AMOX ® Amoxicillin

The use of AMOX ® is contraindicated in patients hypersensitive to penicillins and cephalosporins or related excipients and in the course of infectious mononucleosis.

Undesirable Effects - Side Effects

Although the intake of AMOX ® is generally well tolerated, the allergenic power of amoxicillin could cause, especially in predisposed patients, the onset of skin rashes, angioedema, bronchospasm, laryngospasm, hypotension and in the most severe cases anaphylactic shock.
Vomiting, diarrhea, anorexia, pseudo-membranous colitis, epigastric pain, hypertransaminasemia, hyperbilirubinemia, headache and dizziness, fortunately rare, could be added to the aforementioned side effects.

Note

AMOX ® is a prescription drug.

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