;
It appears that "HCA can promote weight loss by inhibiting a particular enzyme - l"adenosine triphosphate citrate lyase - whose task is to convert citrate into oxaloacetate and acetyl-coenzyme A (Ac-CoA) in the liver. In fact, acetyl-CoA is the starting substrate for the synthesis of fatty acids, triglycerides and cholesterol.
There are numerous and conflicting opinions regarding the real effectiveness of Garcinia cambogia. In fact, several studies have been conducted on this subject and the results obtained are somewhat conflicting.
Garcinia cambogia: does it work?
While some researches conducted have affirmed the usefulness of Garcinia cambogia as an ADJUVANT in slimming treatments, other works have instead shown that preparations based on this plant are not as effective as placebo.
Despite the still heated debate about the anti-obesity properties of this particular species of garcinia, numerous food supplements are available on the market that generally contain it, titrated at 50-60% in hydroxyacetic acid.
It seems, in fact, that the intake of Garcinia cambogia extract is able to increase endogenous levels of serotonin. This increase associated with concomitant SSRI therapy may therefore favor the onset of serotonin intoxication, also defined as serotonin syndrome.
Likewise, Garcinia cambogia and products containing it can establish interactions with tricyclic antidepressants, dextromethorphan, pethidine, pentazocine and tramadol. Finally, since Garcinia cambogia can alter blood sugar, it could also interfere with the action of drugs to treat diabetes.
Therefore, before taking any preparation based on Garcinia cambogia - especially if you suffer from particular pathologies and / or if you are already taking other medicines - it is always good to ask for the preventive advice of your doctor.
and vomiting) and headache.Although the short-term use of preparations based on Garcinia cambogia does not seem to cause particularly serious side effects, there are several studies that are being conducted on the adverse reactions that may occur, however, following the consumption of the products for long periods. of garcinia.
In fact, some cases of liver toxicity have been reported in patients who have made a prolonged use of supplements based on this plant. For this reason, several studies are underway to verify the real risk-benefit ratio that can derive from the use. long-term use of Garcinia cambogia preparations.
known to the plant or to one of its components. It is also contraindicated for use in patients with diabetes, liver disease, dementia, cardiovascular disease and / or hypertension.
As a precaution, the use of Garcinia cambogia is also contraindicated in pregnant women and breastfeeding mothers.
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