To carry out its therapeutic action, triprolidine must be taken orally. However, it is an active ingredient that is never administered alone, but always in association with other active ingredients, such as decongestants such as pseudoephedrine, analgesics and antipyretics such as paracetamol and in some cases, antitussives such as dextromethorphan.
The medicines containing triprolidine currently on the market in Italy (March 2020) are all over-the-counter (OTC) drugs, therefore, which can be purchased without having to present a medical prescription, the cost of which is fully borne by the citizen (class C drugs).
Examples of Medicines containing Triprolidine
- Actifed® (in combination with pseudoephedrine)
- Actifed Compound® (in association with pseudoephedrine and dextromethorphan)
- Actigrip® (in combination with pseudoephedrine and paracetamol)
, etc.) in order to allow him to identify any contraindications to the use of triprolidin and the products that contain it and to identify any situations / conditions that require a certain degree of attention or caution.
In particular, it is emphasized that triprolidine should only be used after a "careful medical evaluation in patients with respiratory conditions, such as emphysema or chronic bronchitis.
Much caution should also be used in patients with liver and / or kidney problems.
In addition, it is reported that triprolidine can cause sedation, thus affecting the ability to drive and use machines.
For more specific information on warnings and precautions for the use of medicines containing triprolidine, please refer to the package leaflet of the medicine to be taken.
of substances that depress the central nervous system, such as sedative-hypnotic drugs (or hypnotic sedatives, if you prefer), tranquilizers, anxiolytics, tricyclic antidepressants, neuroleptics, etc. For this reason, it is very important for patients being treated with one or more of the above drugs to inform their doctor before they start taking any medicine containing triprolidine.
Additionally, antihistamines such as triprolidine can:
- Reduce the duration of action of oral anticoagulants;
- Mask the early signs of ototoxicity caused by certain types of antibiotics.
In any case, before starting to take this active ingredient, the physician should be informed if the patient is taking, has recently taken or might take any medicines or products of any kind - even if not mentioned above - including non-mandatory drugs. prescription (SOP), over-the-counter (OTC) medicines, herbal and phytotherapeutic products, homeopathic products, etc.
For more information about the specific drug interactions of triprolidine-containing medicines, please refer to the package leaflet of the medicine to be used again.
Triprolidine and Alcohol
Triprolidine may enhance the sedative effects of alcohol. For this reason, patients should avoid the consumption of alcohol while being treated with medicines containing this active ingredient.
, manifesting undesirable effects different in type and intensity, or not manifesting them at all.
Although triprolidine and medicines containing it are well tolerated in most cases, it is capable of inducing drowsiness and sedation. The possible onset of allergic reactions in sensitive individuals should not be excluded.
The undesirable effects induced by the active substance in question could however be greater than those listed. Furthermore, the other active ingredients found in association with triprolidine can also cause undesirable effects; for more information, see the package leaflet of the medicine you are taking.
Triprolidine overdose
Taking excessive doses of triprolidine can cause:
- Drowsiness;
- Lethargy
- Respiratory depression;
- Hypertension or hypotension;
- Hyperthermia;
- Anticholinergic syndrome (mydriasis, redness, fever, dry mouth, urinary retention, reduced borborygmas);
- Tachycardia;
- Nausea;
- He retched;
- Agitation;
- Confusional state;
- Hallucinations;
- Psychosis;
- Convulsions;
- Arrhythmias.
Of course, excessive doses of the other active ingredients usually associated with triprolidine can also cause more or less severe symptoms. For this reason, in case of triprolidine overdose - therefore, from medicines that contain it - ascertained or presumed to be, it is advisable to contact your doctor immediately or go to the nearest hospital, taking care to take the package of the medicine taken with you.
H1 of first generation histamine. Chemically speaking, it belongs to the group of alkylamines which, compared to other first generation antihistamines, seem to induce less sedation.
In any case, triprolidine carries out its action by competitively and reversibly inhibiting the H1-type histamine receptors, with consequent symptomatic relief in diseases characterized in part or totally by disorders, including allergic ones.
Triprolidine also exerts anticholinergic activities.
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