The use of similar medicines, therefore, is indicated in all those patients in whom the blood levels of the aforementioned fats are so high as to constitute a pathological condition capable of compromising their health and endangering their life.
Fibrate drugs can be administered both as monotherapy and in combination therapy with other drugs indicated in the treatment of dyslipidemias, such as statins. However, it should be noted that fibrates are not first choice drugs for the treatment of hypercholesterolemia and hypertriglyceridemia.
of cholesterol and triglycerides. To be fair, it should be noted that fibrates are able to more effectively reduce high levels of triglycerides than cholesterol, for this reason, they are generally used when hypercholesterolemia is also associated with hypertriglyceridemia.
From the chemical point of view, the fibrates are analogues of phenoxyisobutyric acid; in this regard, it should be remembered that, for the carrying out of the therapeutic action, the presence of the isobutyric group is of fundamental importance. The fibrates currently available on the market are, in fact, prodrugs that become active - carrying out their activity - only after undergoing metabolism.
