it depends on the loss of nerve cells in an area of the brain, called the substantia nigra, which intervenes in the correct execution, control and coordination of movements. The nerve cells in this area produce dopamine, a chemical substance that acts as a messenger: if neurons are damaged, a deficiency of this neurotransmitter occurs, and the areas that regulate body movements do not function properly, causing movement to slow down and lack of coordination.
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At the same time, a protein, called alpha-synuclein, can accumulate in the brain, which promotes the degeneration of neurons.
The loss of nerve cells is a slow process, and the symptoms of Parkinson's disease typically occur when approximately 80% of the nerve cells in the substantia nigra have already been lost.
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