About HMB - Anderson
HMB - Anderson
Food supplement based on hydroxy beta methyl butyrate
FORMAT
Bottle of 100 tablets
COMPOSITION
Hydroxy beta methylbutyrate (HMB): salified with calcium
Capsule: food gelatin
Stabilizer: microcrystalline cellulose
Anti-caking agents: Magnesium stearate, silicon dioxide.
One tablet contains: 750 mg hydroxy beta methyl butyrate
Product features HMB - Anderson
Hydroxy beta methyl butyrate- produced starting from alpha ketoisocaproate ketoacid, in turn obtained by transamination of the amino acid leucine, hydroxy methyl butyrate, is part of the regulation of protein homeostasis with mechanisms not yet fully known.
Experimental evidence suggests a direct involvement of this molecule in:
- Activate mTOR, with a consequent increase in protein synthesis;
- Reduce protein degradation, via ubiquitin proteasome;
- Protect the cell from ROS-mediated oxidative insult;
- Reduce the activation of caspases, preserving the cell from apoptosis (programmed cell death).
From an application point of view, this would translate into an improvement in protein turnover, an increase in muscle mass and an "antioxidant and cytoprotective activity. The various studies, many of which are still in the experimental phase, have shown the possibility of preventing cachexia in subjects affected by cancer or AIDS, in maintaining muscle mass in elderly individuals, in strengthening the immune defenses (increase in facogitic abilities) and in improving the lipidemic profile.
With regard to applications in the sports field, we are evaluating:
- Ergogenic effect (increase in strength and endurance);
- Antioxidant and protective effect against damage induced by intense physical exercise;
- Redistribution of body composition (increase in lean mass and decrease in fat mass).
Rationale for integrating HMB - Anderson into sports practice
From the careful re-reading of scientifically valid publications concerning HMB, very contrasting data emerges regarding its effectiveness in sports practice. In fact, several studies show an increase in strength and resistive capacities, with a possible improvement in oxidative metabolism, a reduction in markers of muscle damage - such as creatinkinase and lactic dehydrogenase - and an increase in lean mass. Others, on the other hand, are very critical, not detecting any kind of benefit.
Although it is not yet possible to draw definitive conclusions, given the low number of individuals recruited for these studies, supplementation with HMB seems to be particularly effective for untrained subjects, while it would be of little use in athletes, as well as in the case of untrained administrations. continued for at least 3/4 weeks.
Method of use recommended by the company - HMB - Anderson
It is recommended to take 2 tablets a day, preferably together with meals. It is recommended not to chew the tablets.
Method of use in sports HMB - Anderson
The dose recommended by the studies, and most used in sports, is that of 3 grams of HMB per day, administered at 3 different times of the day, in order to reduce renal elimination.
The administration of 1 g at a time was chosen both for the half-life of about 2.5 hours and for the lowering of plasma levels (about 9 h), and for the levels of urinary excretion, which are at a minimum around 14%.
Given the product in question, with 750 mg capsules, the intake could be divided into one capsule in the morning, 1 pre-workout, 1 post-workout and one before going to bed.
It is necessary to specify that a particularly studied integrative protocol is difficult to put in place, due to the absence of data relating to the method of distribution of the compound, and to the biological effects.
How to optimize your business HMB - Anderson
There are studies in the literature that show the efficacy of HMB in synergy with glutamine and arginine, in improving protein turnover, and counteracting the cachectic effect that occurs in some serious pathologies.
A similar effect was observed on healthy and elderly individuals after one year of supplementation with arginine, lysine and HMB.
On the other hand, the synergy between creatine and HMB seems ineffective.
Furthermore, it could also theoretically be justified to administer it simultaneously with BCAAs to preserve muscle mass from proteolysis induced by intense physical exercise.
HMB Side Effects - Anderson
The administration of HMB appears to be well tolerated at doses ranging from 3 to 6 grams per day, and well documented in the literature even for several weeks of administration.
Animal studies also show that very high doses are however tolerated.
A reduction in blood pressure has been recorded in some studies following the administration of HMB, but this appears to be due to the presence of calcium in the product.
Precautions for use HMB - Anderson
The product is contraindicated in cases of renal or hepatic pathology, cardiovascular disease and / or hypertension, in pregnancy, during lactation, under 12 years and in adolescents not yet trained.
In case of prolonged use (over 6/8 weeks) the doctor's opinion is necessary.
This article, elaborated on the critical rereading of scientific articles, university texts and common practice, is for information purposes only and therefore has no medical prescription value.It is therefore always required to consult your doctor, nutritionist or pharmacist before undertaking the use of any supplement.. Learn more about HMB's critical analysis - Anderson.
The prevention and treatment of exercise-induced muscle damage.
Howatson G, van Someren KA.
Sports Med. 2008; 38: 483-503. Review.
Beta-hydroxy-beta-methylbutyrate (HMB) supplementation and the promotion of muscle growth and strength.
Slater GJ, Jenkins D.
Sports Med. 2000 Aug; 30: 105-16. Review.
Beta-hydroxy-beta-Methylbutyrate and its use in athletics.
Palisin T, Stacy JJ.
Curr Sports Med Rep. 2005 Aug; 4: 220-3. Review.
Exercise-induced muscle damage is not attenuated by beta-hydroxy-beta-methylbutyrate and alpha-ketoisocaproic acid supplementation.
Nunan D, Howatson G, van Someren KA.
J Strength Cond Res. 2010 Feb; 24: 531-7.
Mechanism of attenuation by beta-hydroxy-beta-methylbutyrate of muscle protein degradation induced by lipopolysaccharide.
Russell ST, Tisdale MJ.
Mol Cell Biochem. 2009 Oct; 330 (1-2): 171-9. Epub 2009 Apr 30.
Effects of nine weeks of beta-hydroxy-beta- methylbutyrate supplementation on strength and body composition in resistance trained men.
Thomson JS, Watson PE, Rowlands DS.
J Strength Cond Res. 2009 May; 23: 827-35.
Effects of beta-hydroxy-beta-methylbutyrate supplementation during resistance training on strength, body composition, and muscle damage in trained and untrained young men: a meta-analysis.
Rowlands DS, Thomson JS.
J Strength Cond Res. 2009 May; 23: 836-46.
Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage.
Wilson JM, Kim JS, Lee SR, Rathmacher JA, Dalmau B, Kingsley JD, Koch H, Manninen AH, Saadat R, Panton LB.
Beta-hydroxy-beta-methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factor-kappaB expression.
Nunes EA, Kuczera D, Brito GA, Bonatto SJ, Yamazaki RK, Tanhoffer RA, Mund RC, Kryczyk M, Fernandes LC.
Nutr Res. 2008 Jul; 28: 487-93.
Effect of beta-hydroxy-beta-methylbutyrate (HMB) on protein metabolism in whole body and in selected tissues.
Holecek M, Muthny T, Kovarik M, Sispera L.
Food Chem Toxicol. 2009 Jan; 47: 255-9. Epub 2008 Nov 21.
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review.
Wilson GJ, Wilson JM, Manninen AH.
Nutr Metab (Lond). 2008 Jan 3; 5: 1.
J Appl Physiol. 1996 Nov; 81: 2095-104.
Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training.
Int J Sport Nutr Exerc Metab. 2001 Dec; 11: 442-50.
Paddon-Jones D, Keech A, Jenkins D.
J Nutr Biochem. 2001 Nov; 12: 631-639.
Effects of amino acids supplement on physiological adaptations to resistance training.
Kraemer WJ, Hatfield DL, Volek JS, Fragala MS, Vingren JL, Anderson JM, Spiering BA, Thomas GA, Ho JY, Quann EE, Izquierdo M, Häkkinen K, Maresh CM.
Med Sci Sports Exerc. 2009 May; 41: 1111-21.
Effects of six weeks of beta-hydroxy-beta-methylbutyrate (HMB) and HMB / creatine supplementation on strength, power, and anthropometry of highly trained athletes.
O "Connor DM, Crowe MJ.
J Strength Cond Res. 2007 May; 21: 419-23.
The effects of beta-hydroxy-beta-methylbutyrate (HMB) and HMB / creatine supplementation on indices of health in highly trained athletes.
Crowe MJ, O "Connor DM, Lukins JE ..
Effects of beta-hydroxy-beta-methylbutyrate and creatine monohydrate supplementation on the aerobic and anaerobic capacity of highly trained athletes.
O "Connor DM, Crowe MJ.
A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl beta-methyl butyrate, glutamine, and arginine mixture for the treatment of cancer cachexia (RTOG 0122).
Berk L, James J, Schwartz A, Hug E, Mahadevan A, Samuels M, Kachnic L; RTOG.
Support Care Cancer. 2008 Oct; 16: 1179-88. Epub 2008 Feb 22.
Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine.
Baier S, Johannsen D, Abumrad N, Rathmacher JA, Nissen S, Flakoll P.
JPEN J Parenter Enteral Nutr. 2009 Jan-Feb; 33: 71-82.
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